Bone defect caused by specific diseases or medications is very common. Autologous bone, allogeneic bone or xenogeneic bone transplantation is commonly used in clinical practice. However, autologous bone sources are limited. Xenogeneic bone cannot participate in metabolism. Because of the development of bone tissue engineering, the transplantation of new scaffold materials and autologous cells has opened up new treatment options for bone defects. 3D printing technology meets these needs very well, which can accurately produce personalized tissue engineering bone scaffolds based on bone defect and CT imaging data, and match the scaffold with the defect areas perfectly, imitate the normal nature tissue microstructure of human. This research focuses on the 3D printed bone tissue engineering scaffolds with various materials and post treatment processes.