ABBA Lab

Advanced Biomaterials for Biomedical Applications Lab

Journal

In-vitro blood and vascular compatibility of sirolimus-eluting organic/inorganic hybrid stent coatings
Year
2019
Author
Tae-Sik Jang, Kwang-Hee Cheon, Ji-Ho Ahn, Eun-Ho Song, Hyoun-Ee Kim, Hyun-Do Jung*
Publication date
2019/7/1
Journal
Colloids and Surfaces B: Biointerfaces
Vol
179(1)
Page
405-413
File
1-s2.0-S0927776519302413-main.pdf (2.4M) 4회 다운로드 DATE : 2020-11-10 11:53:52
The surface characteristics of coronary stents play a pivotal role in inhibiting in-stent restenosis and late-stent thrombosis. In this study, a sol-gel-derived silica xerogel-chitosan hybrid coating was applied to Co-Cr stent and was reported, for the first time, as a biocompatible drug delivery tool in vascular stent application. A dense and uniform chitosan-silica xerogel hybrid coating (<1-μm thick) was applied on bare Co-Cr material. Sirolimus was well incorporated into the hybrid coatings without re-crystallization. The chitosan-silica hybrid coating with 30 wt% silica xerogel showed better mechanical stability and good adhesive strength without any cracking or delamination. The chitosan-silica hybrid coated Co-Cr surface exhibited significantly improved wettability and corrosion resistance compared to the chitosan coated Co-Cr surface. In addition, the hybrid coating layer enabled efficient loading of sirolimus, owing to the unique mesoporous structure of silica xerogel, which further allowed the sustained release of sirolimus over 3 weeks. In-vitro tests with human umbilical cord vein endothelial cells and blood platelets confirmed that the chitosan-silica hybrid coating had excellent cytocompatibility and hemocompatibilty. Thus, this study demonstrated that the chitosan-silica hybrid material is a promising material for coating coronary stents, with minimal risk of in-stent restenosis and thrombogenicity.