ABBA Lab

Advanced Biomaterials for Biomedical Applications Lab

Journal

Bifunctional poly (L-lactic acid)/hydrophobic silica nanocomposite layer coated on magnesium stents for enhancing corrosion resistance and endothelial cell responses
Year
2021
Author
Suhyung Park, Hyun Lee, Hyoun-Ee Kim, Hyun-Do Jung*, Tae-Sik Jang
Publication date
2021/8
Journal
Materials Science and Engineering: C
Vol
127
Page
112239
File
mse-c.pdf (8.4M) 1회 다운로드 DATE : 2021-06-12 16:34:44
Biodegradable magnesium (Mg)-based vascular stents can overcome the limitations of conventional permanent metallic stents, such as late in-stent restenosis and thrombosis, but still have difficulty retarding degradation while providing adequate mechanical support to the blood vessel. We incorporated silica nanoparticles surface-functionalized with hexadecyltrimethoxysilane (mSiNP) into a poly (L-lactic acid) (PLLA) coating as a physical barrier to disturb the penetration of the corrosive medium as well as a bioactive source that releases silicon ions capable of stimulating endothelial cells. The corrosion resistance and biocompatibility of this bifunctional PLLA/mSiNP nanocomposite coatings were investigated using different weight ratios of mSiNP. The nanocomposite coating containing more than 10 wt% of the mSiNP (PLLA/10mSiNP and PLLA/20mSiNP) significantly delayed the corrosion of the Mg substrate …