ABBA Lab

Advanced Biomaterials for Biomedical Applications Lab

Journal

Functionally assembled metal platform as lego-like module system for enhanced mechanical tunability and biomolecules delivery
Year
2021
Author
Hyun Lee, Min-Kyu Lee, Kwang-Hee Cheon, In-Gu Kang, CheonIl Park, Tae-Sik Jang, Ginam Han, Hyoun-Ee Kim, Juha Song, Hyun-Do Jung*
Publication date
2021/9
Journal
Materials & Design
Vol
207
Page
109840
File
Functionallyassembledmetalplatformaslego-likemodulesystemforenhancedmechanicaltunabilityandbiomoleculesdelivery 1.pdf (3.3M) 8회 다운로드 DATE : 2021-06-12 16:35:59
Natural bone substituting materials derived from living organisms have been utilized to treat bone mal-functioning. However, limited sources and immune issues have led to the use of artificial scaffolds con-sisting of biocompatible materials. Additionally, a functionally graded porous structure has beenacknowledged as an alternative to overcome reduced mechanical properties by pores and alleviate stressshielding effect. In this study, a two-body combination achieved through a densification process, in whichrecombinant human bone morphogenetic protein-2 (rhBMP-2) and tetracycline hydrochloride (TCH) canbe simultaneously released for efficient bone regeneration, is proposed. Biomimetic titanium scaffolds(BTSs), which possess significantly different pore characteristics, are successfully fabricated. The mechan-ical properties of these parts are proven to be applicable as bone substitutes. The release of rhBMP-2 andTCH from the BTSs is prolonged compared to that of homogenous porous titanium scaffolds (PTSs). Theprolonged release of rhBMP-2 from the BTS results in a sustained degree of pre-osteoblast differentiation.The antimicrobial properties of these scaffolds are verified using pathogens. Furthermore, various struc-tures exhibiting different pore characteristics are obtained by mechanical interlocking between compo-nents. This study demonstrates that the novel assembled platform as customizable Lego-like building blocks, with its tunable mechanical and multi-biomolecule release properties, is promising for bone tis-sue engineering.