ABBA Lab

Advanced Biomaterials for Biomedical Applications Lab

Journal

Design and Usability Evaluations of a 3D‐Printed Implantable Drug Delivery Device for Acute Liver Failure in Preclinical Settings
Year
2021
Author
Shin‐Young Kim, Ginam Han, Da‐Bin Hwang, Dong‐Hoon Won, Yoo‐Sub Shin, Changuk Kim, Jeon Min Kang, Jung‐Hoon Park, Hyun‐Do Jung*, Wooram Park, Jun‐Won Yun
Publication date
2021/7
Journal
Advanced Healthcare Materials
Vol
10(14)
Page
2100497
File
adhm.202100497 2.pdf (4.0M) 6회 다운로드 DATE : 2021-07-22 09:31:30
Acute liver failure (ALF) requiring liver transplantation is a disease that occurs due to rapid hepatocellular dysfunction. As liver transplantation has various limitations, including donor scarcity, high cost, and immuno‐incompatibility, continuous local delivery of biopharmaceuticals to the liver tissue can be a promising ALF treatment option. Here, the in vivo safety and usability of a 3D‐printed implantable drug delivery device for effective ALF treatment is evaluated. The implantable reservoir consists of a 3D‐printed container and a semipermeable membrane for repeated administrations of drugs, specifically to the liver tissue. The physical stability and function of the 3D‐printed reservoir are confirmed by the mechanical properties and in vitro drug release test, respectively. In mice implanted with the reservoir system, mortality, weight changes, clinical signs, hematological and serum biochemical changes, and organ …