ABBA Lab

Advanced Biomaterials for Biomedical Applications Lab

Journal

A combination strategy of functionalized polymer coating with Ta ion implantation for multifunctional and biodegradable vascular stents
Year
2021
Author
Kwang-Hee Cheon, Cheonil Park, Min-Ho Kang, Suhyung Park, Jinyoung Kim, Seol-Ha Jeong, Hyoun-Ee Kim, Hyun-Do Jung*, Tae-Sik Jang
Publication date
2021/11/15
Journal
Journal of Magnesium and Alloys
Vol
9(6)
Page
2194-2206
File
1-s2.0-S2213956721001961-main 2.pdf (2.8M) 7회 다운로드 DATE : 2022-01-25 09:59:47
Biodegradable stents made of magnesium (Mg) and its alloys have been developed to minimize persistent inflammation or in-stent restenosis, which are the main problems for permanent stents. However, their rapid corrosion behavior under physiological conditions leads to poor vascular compatibility and premature structural failure, which remains an important unsolved clinical problem. Herein, we demonstrate a new strategy for solving this problem by combining poly (ether imide) (PEI) coating and subsequent tantalum (Ta) ion implantation. The PEI coating covers the whole surface of the Mg stent uniformly via a spray coating technique and provides Mg with superior corrosion resistance and stable sirolimus-carrying ability. Ta ion implantation is conducted by a sputtering-based plasma immersion ion implantation technique only onto the luminal surface of the PEI-coated Mg stent. Its extremely short processing …