ABBA Lab

Advanced Biomaterials for Biomedical Applications Lab

Publication
- Introduction
- Member
- Research
- Publication
- Board
Journal
- Journal
- Patent

Journal 글답변

html

이름*

비밀번호*

Year of publication*

Title*

Author

Publication date

Journal

Status

Vol

Page

웹에디터 시작

> 
 > 
 > Magnesium and its alloys are promising materials for biodegradable drug-eluting stent applications, but their rapid corrosion remains a major challenge for clinical practice. Considerable efforts have been made to develop an efficient surface coating that can provide higher Mg stent corrosion resistance, sustained drug-delivery capability, and vascular compatibility. Herein, we introduce poly(ether imide) (PEI) and poly(lactic-co-glycolic acid) (PLGA) as surface coating polymers for WE43 Mg-alloy stent. Using a sequential spray-coating method, we developed a novel asymmetric stent coating comprising an inner surface coated with a PEI single layer and outer/side surfaces coated with sirolimus-loaded PLGA/PEI double layers. PEI coating layer has excellent adhesiveness to WE43 surface and considerably improves WE43 corrosion resistance and in vitro endothelial cell compatibility. PLGA/PEI double coating layer ensures a low release rate of sirolimus and stable surface morphology during drug-release process. Only vascular smooth muscle cells are directly affected by sirolimus owing to the asymmetric geometry of PLGA/PEI double coating, which has a satisfactory anti-proliferation effect. These results indicate that the developed asymmetrically PEI- and PLGA/PEI-coated WE43 stents have significant potential for achieving enhanced re-endothelialization and suppressed in-stent restenosis in vascular stent applications.
 > 
 >

웹 에디터 끝

링크 #1

링크 #2

파일 #1

파일 #2

자동등록방지

자동등록방지 숫자를 순서대로 입력하세요.

취소